Background: Morbid obesity is defined as a body weight 160% above the ideal weight for survival or 40 kg/m2 or >35 with serious comorbidity. Long-term surveys revealed that surgical intervention has been the only method to effectively sustain weight loss in these patients. Objectives: To compare total intravenous anesthesia applied with propofol-fentanyl to sevoflurane single breath and maintenance anesthesia. Patients and Methods: This prospective randomized clinical study was approved by the ethics committee in AlAzhar University and a written informed patient's consent was obtained. This study included 50 patients of both sexes, admitted for bariatric surgery carried out at Al-Azhar University Hospitals (El-Hussein and Bab El-Sharia). They were randomly allocated into two equal groups, TIVA group: 25 patients will receive total intravenous anesthesia applied with propofol-fentanyl. Group VIMA: sevoflurane single breath induction and maintenance group: 25 patients will receive - sevoflurane single breath induction and maintenance. Results: Total intravenous anesthesia using (fentanyl and propofol). Volatile induction and maintenance anesthesia (Inhalational anesthesia) using (fentanyl and sevoflurane). The following parameters were assessed between the 2 groups: Hemodynamics, SPo2 and ET Co2 were continuously monitored and recorded at 15 min interval. Conclusion: This study showed that both TIVA and VIMA were effective in bariatric surgeries. Regarding neuroendocrine stress response, TIVA group was provided suppressed hormone levels suggesting that there was suppression of stress response unlike VIMA group that showed even raised serum levels of those hormones.