Background: age-related macular degeneration (AMD) is a macular neurodegenerative disease that nowadays constitutes one of the main socioeconomical health issues worldwide, affecting the elderly population. The exponentially increasing prevalence of AMD is linked to progressive aging of the population, and it is the leading cause of legal blindness in the developed world. Objective: the study was designed to assess the relation between fundus autofluorescence (FAF) and Optical Coherence Tomography (OCT) in cases of age related macular degeneration. Patients and Methods: this study is prospective randomized, non-interventional uncontrolled cross-sectional study was conducted on thirty patients. These patients already diagnosed to have age related macular degeneration either dry or wet form by fundus examination. Results: it was found from this study fifty eyes of thirty patients having AMD, Sex distribution in female more than male, age distribution revealed that the age ranged from 50 to75 years, FAF and OCT cannot replace FFA in cases of CNV. Conclusion: FAF provides the opportunity to evaluate the retinal functional status. OCT obtains a detailed picture of the retinal anatomy