Background: psoriasis is a chronic, inflammatory skin disease that causes significant distress and morbidity. Objective: the aim of this study was to compare the efficacy of PDL plus topical calcipotriol and corticosteroid combination versus topical calcipotriol and corticosteroid combination in the treatment of nail psoriasis. Patients and methods: thirty patients with bilateral fingernail psoriasis were recruited from the Dermatology Outpatient Clinic at Al Hussein Hospital, Al Azhar University and Al-Haud Al-Marsoud Hospital between September 2014 and February 2017. Results: regarding treatment sessions, total treatment sessions, follow up sessions or total follow up sessions, there was no statistically significant difference (p-value > 0.05) between right hand and left hand. There was no statistically significant difference (p-value > 0.05) between the 2 subgroups (< 30 years and > 30 years), (male and female) or (skin type 3 and type 4) as regard 1st, 2nd, and 3rd treatment session. There was highly statistically significant (p-value < 0.001) positive correlation between (1st Rt. Vs 2nd Rt.) and (2nd Rt. Vs 3rd Rt.) treatment sessions. Also, statistically significant (p-value < 0.05) positive correlation between (first Rt. Vs 3rd Rt.) treatment sessions. Conclusion: laser therapy had been shown to be effective and safe for nail psoriasis. It could be used alone or combined with different therapeutic modalities, being especially beneficial with topical treatments.