Background: Chronic cutaneous lupus erythematosus (CCLE) is limited to the skin, commonly affecting the face, frequently disfiguring and sometimes therapeutically challenging. Cutaneous lupus erythematosus has been treated with different laser in many studies and reports with promising results, presenting another new line of CCLE treatment. Aim of the work: This work aimed to evaluate and compare between the efficacy and safety of pulsed dye laser (PDL) versus ND: YAG laser for CCLE treatment. Patients and methods: This comparative study included a total of twenty patients with CCLE who had active lesion and with histologically confirmed lupus erythematosus, attending at Dermatology Outpatient Clinic of Al-Azhar University Hospitals. The patients were divided into 2 groups; group (A): 20 patients were treated by PDL and group (B): 20 patients were treated by ND:YAG laser. The degree of CCLE and clinical response evaluation was assessed using CLASI system. Results: In both groups A & B clearance rate was equal (50%) and Improvement rate was 100% with significant decline in ‘‘active'' CLASI after laser treatment in both groups. P-value was 0.04 in group A and 0.005 in group B, without significant difference between both groups. Conclusion: PDL and ND: YAG laser are safe and effective in CCLE treatment with insignificant difference between them. So, we recommend early laser usage as main treatment of CCLE particularly for refractory cases for other treatment line or as an adjunctive therapy to decrease incidence of atrophy and scarring.