Background: Radial Artery catheterization is a fundamental approach that is used as a procedural access in the different catheterization interventions in more than 90% of procedures due to low prevalence of access-related complications. Aim of the work: The aim of the study was to develop and to implement a new radial artery access (located at hand) for performing endovascular interventions. Also, our object to reduce the rate of access-related complications by comparison between the traditional radial access and new trans distal radial approach by history and Doppler investigation and follow up. Materials and methods: This was a clinical trial study that included 100 patients who presented to the Cardiology Departments in El Sayed Galal Hospital to perform planned trans radial coronary angiography and coronary intervention for diagnosis and treatment of ischemic heart events. The study was carried out on 100 patients that were divided into two groups, one group had 50% of patients underwent the procedure through the traditional Trans radial approach and the other half of the patients underwent the procedure through the new approach (The Anatomical Snuffbox). Results: the results revealed that Complication higher in radial but not significant (12% in Snuff- box group and 24% in Radial group). Conclusion: To be proficient with both approaches, the operator needs to understand the differences between these two routes in terms of patient preparation, procedural technique, catheter selection and laboratory setup.