Background: Over the last decades, the incidence of pancreatic cancer has increased. It is the seventh most common cause of cancer deaths especially in the developed world. Objective: This study aims to evaluate the efficacy of computed tomography (CT) guided celiac plexus neurolysis (CPN) to relieve intractable abdominal pain caused mainly by abdominal malignancy. Patients and Methods: This prospective study included 20 adult patients; some of them were referred from Oncology Department and others were from outpatient clinic. Patients had abdominal pain owing to abdominal cancer during the period from October 2018 to May 2019 in Al-Hussien and Bab-Alsheria Hospitals, Al- Azhar University. Results: CT-guided celiac plexus block was successfully carried out for the patients. 13 of them (65%) were males and 7 (35%) were females, with mean age of 57.05 years. Abdominal pain in the 20 patients was owing to infiltrative or metastatic hepatocellular carcinoma in ten (50%) patients, pancreatic cancer in six (30%) patients, lymphoma in two (10%) patients, gastric cancer in one (5%) patient, and metastatic lung in cancer one (5%) patient. Conclusion: The current study disclosed the incremental value of the CT-guided CPN via using different techniques with injection of 20–40 mL of 95% of ethanol neurolytic solution as an ideal palliative treatment for eradication of severe pain mainly caused by unresectable pancreatic cancer.