Background: Gastric cancer is the third most common cause of cancer-related death in the world. Currently, multislice computed tomography (MSCT) is a valuable tool for detection, staging, surveillance, and post-treatment evaluation of gastric neoplasm. Objective: The aim of this work is to clarify the role of multidetector CT in diagnosis and preoperative staging of gastric carcinoma. Patients and methods: The present study was conducted between October 2017 and June 2019 on 60 patients (26 males and 34 females) with age ranged from 28 to 73 years with mean age of 53 years. The patients were complaining of symptoms of gastric cancer or as a follow-up study for gastric cancer, referred to the CT Unit in Tanta University Hospital, Tanta Oncology Center and Health Insurance Hospital from the Oncology Department. Results: In our study we found that there was a significant relationship between pathological and CT staging by using MPR. CT with MPR was specific and accurate in diagnosis of all stages of gastric cancer with specificity ranged between (95-100%) and accuracy ranged between (94.5-97.5%). However, it showed lowest sensitivity in diagnosis of stage 1 of gastric cancer. On the other hand, it showed highest sensitivity (97.5%) in diagnosis of stage IV. Conclusion: MSCT is a valuable tool for detection, staging, surveillance, and post-treatment evaluation of gastric neoplasm.