Background: pesticides are pivotal for pest control. However, due to their cumulative nature humans are vulnerable to daily sub-lethal exposure with increased risk for clinical disorders including kidney diseases. Oxidative stress is the main proposed mechanism for pesticides biohazards. Aim of this study: to clarify the effect of exposure to emamectin benzoate (EMB) on structure and ultrastructure of the kidney of adult male albino rats and the possible protective effect of aqueous ginger nanoparticles extract (GNE) on these changes. Materials and Methods: four groups were incorporated in this study, six animals each. GI: control group; GII: received aqueous GNE (100 mg/kg/d); GIII: received EMB (5 mg/kg/d); GIV: received EMB and aqueous GNE. Initial/final body weight (BW) variations and biochemical tests of serum creatinine (sCr) and blood urea nitrogen (BUN) were assessed. After one month, both kidneys from all groups were excised under anesthesia and prepared for light and electron microscopic assessment. The results were statistically evaluated. Results: comparing mean final BW among all groups revealed insignificant decrease in BW of GIII. There was a significant increase in the mean final sCr and BUN in GIII which was improved in GIV (p< 0.001). There was a significant increase in area percent of both collagen fibers deposition and Bax immune-expression in GIII which was markedly diminished in GIV (p< 0.001). Morphologic alternations were detected in kidney of rats of GIII which was ameliorated in GIV. Conclusion: EMB altered kidney morphology and aqueous GNE exerted an ameliorative effect.