Background: Multidetector computed tomography (MDCT) is a useful, less invasive technique for diagnosing most types of vascular variations. CT is superior to radiology for identification of normal anatomy, anatomic variants and early abnormalities or pathological processes. Objective: The aim of this work was to evaluate the role of MDCT in Assessment of great chest vessels Anomalies. Patients and methods: The study included 30 patients in the age group between 2 months up to 30 years with a mean of 3 months. All patients were referred for evaluation Great chest vessels anomalies suspected to be in association with congenital heart disease. Results: CT provide an accurate assessment of Aortic vessel (Ascending, Arch and descending parts) four cases diagnosed as moderate to severe Aortic coarctation, two cases diagnosed as supravalvular and subvalvular aortic stenosis, two cases associated with right sided Aortic Arch, one case with hypoplastic Aortic Arch and another case had tortuous course of the Aorta. Substantial benefit of CTA is depiction of airway compromise owing to aortic rings. In the setting of coarctation, collateral vessels are better displayed. Conclusion: It could be concluded that the nowadays ease of the scan acquisition, the high spatial resolution and the accurate assessment of modern CT techniques make CT chest angiography an investigation ideally suited for the great chest vessels anomalies.