Background: surgical treatment for patients with concurrent glaucoma and cataract includes sequential surgery and combined phacotrabeculectomy. When combined surgery is planned, the next issue that must to deal with is whether two-site surgery is better or one-site surgery. Aim: the study aimed to compare the outcomes and to report on the efficacy and safety of the two procedures. Patients and Methods: this prospective randomized comparative interventional study included fifty subjects. Patients were recruited from those who attended to the outpatient Ophthalmology Clinic of Sayed Galal hospital, Al-Azhar University. The study was conducted in the period from October 2016 until May 2018. Patients were randomized into two groups: Group I (n=25), who was subjected to one-site phacotrabeculectomy and Group II (n=25), who was subjected to the two-site procedure performed by one experienced anterior segment surgeon. Results: no significant differences were observed in the main outcome measures of IOP and the need for supplemental antiglaucoma medications between the two glaucoma groups. Conclusion: both surgical techniques were effective in reducing IOP and to eliminate the need for antiglaucoma medications in many eyes over the entire study period.