33361

Accelerated versus Conventional Corneal Collagen Cross-Linking in The Treatment of Keratoconus

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Last updated: 03 Jan 2025

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Abstract

Background: corneal collagen cross-linking (CXL) is one of the interesting topics in corneal surgery, with several recent modifications of the original Dresden protocol under investigation. Accelerated CXL is one of the exciting modifications of the original technique but with few published results. It Objective: the aim of the present study was to compare the effect of accelerated (both continuous and pulse) crosslinking on the keratoconic cornea versus conventional protocol. We stuck to inclusion and exclusion criteria of the study. Patients and methods: in this study we evaluated 90 eyes; 30 eyes received standard Dresden protocol (S-CXL), 30 eyes received continuous light accelerated protocol (cl-ACXL), and 30 eyes received pulsed light accelerated protocol (pl-ACXL). The refractive status, visual acuity, corneal topography, central corneal thickness and corneal biomechanics were evaluated preoperatively, at 1 st month, 3rd month, 6th month and 12th month postoperative. Results: all groups showed an improvement of MRSE, UCVA and BCVA one year after surgery. The central corneal thickness (CCT) markedly decreased at 1st month follow-up, then gradually increased till 12th month but still below the baseline. Both maximum and minimum keratometry (K-max and K-min) decreased significantly at 12th month follow-up. The corneal biomechanics; corneal hysteresis (CH) and corneal resistance factor (CRF) showed no significant changes all over the follow-up period. Conclusion: the results in this study showed that both continuous and pulsed light accelerated cross-linking are as safe as standard Dresden protocol in halting keratoconus disease.

DOI

10.21608/ejhm.2019.33361

Keywords

CXL, Keratoconus

Authors

First Name

Hosny Hassan

Last Name

Mohammad

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Affiliation

Department of Ophthalmology, Faculty of Medicine – Al-Azhar University

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First Name

Sayed Abbas

Last Name

Sayed

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Affiliation

Department of Ophthalmology, Faculty of Medicine – Al-Azhar University

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First Name

Abdelghany Ibrahim

Last Name

Abdelghany

MiddleName

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Affiliation

Department of Ophthalmology, Faculty of Medicine – Al-Azhar University

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First Name

Mohamed El-Sayyed Mokhtar

Last Name

El-Sayyad

MiddleName

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Affiliation

Department of Ophthalmology, Faculty of Medicine – Al-Azhar University

Email

m_sayyad@hotmail.com

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Volume

75

Article Issue

5

Related Issue

5450

Issue Date

2019-04-01

Receive Date

2019-05-26

Publish Date

2019-04-01

Page Start

2,871

Page End

2,877

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_33361.html

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https://ejhm.journals.ekb.eg/service?article_code=33361

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Accelerated versus Conventional Corneal Collagen Cross-Linking in The Treatment of Keratoconus

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Article

Created At

22 Jan 2023