Background: skeletal muscle relaxants are a varied set of drugs which treat pain of muscles or shudders from marginal musculoskeletal circumstances. Aim of the work: this work targeted to detect the histopathological and histochemical alternations in the rats fetal esophageal treated maternally with Carisoprodol (Soma). Material and methods: thirty gravid rats were branded into three sets: 1-Rats of the 1 st group served as the control group and they were administered oral doses of distilled water, 2- Group of 10 pregnant rats served as the 2nd group and they were treated daily with 10.8 mg/100g/day b.wt. of Carisoprodol, 3-In group 3 pregnant rats were treated with 21.6 mg/100g body weight/day of Carisoprodol (treatment started from the 6th till the 20th day of gestation). Pregnant mothers were sacrificed and small sections of fetal rat esophagus were taken for the histopathological and histochemical purposes. Results: numerous histopathlogical and histochemical changes were detected in the fetal esophageal tissue of the two treated groups compared to the control group and the alternations were amplified with raising the doses of carisoprodol. Conclusion: treatment of the pregnant rats with carisoprodol caused dystrophic variations in the fetal esophageal tissue, so the usage of this medicine during gestation should be under strict protections.