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30105

Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure

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Last updated: 03 Jan 2025

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Abstract

Background: Infertile couples to have healthy children are one of primary tasks of assisted reproductive technologies. In order to fulfill these tasks, reproductive medicine constantly needs to obtain information on physiology and pathophysiology of infertility and to develop efficient strategies for ovarian hyper-stimulation. Objectives: Aim of the current Work was to evaluate the efficacy of oral sildenafil citrate 25 mg on pregnancy outcome, endometrial thickness, pattern and uterine arteries Doppler blood flow in patients with 3 or more concoctive unexplained recurrent IVF/ICSI implantation failure. Patients and Methods: This prospective, randomized, double blinded study included a total of seventy patients undergoing ICSI trial attending at the University Maternity Hospital IVF\ICSI unit. The included subjects were randomly allocated into two groups: Group I (study group): included 35 women with recurrent ICSI implantation failure with another trial of ICSI using the standard drugs and technique with the addition of sildenafil 25 mg orally twice daily. Group II (control group): included 35 women with recurrent ICSI implantation failure with another trial of ICSI using the standard drugs and technique (control group). Results: The statistical comparison between group I (Sildenafil Citrate) and group II (control) regarding endometrial thickness showed non significant differences before and significant differences after 21days of administration of Sildenafil Citrate. The statistical comparison in patients in group I (Sildenafil Citrate) regarding Pulsatility index, Resistance index and Systolic/ diastolic ratio showed significant differences of these parameters. Conclusion: It could be concluded from this study that adding of sildenafil citrate 25 mg orally twice daily for 21 days to patients with unexplained recurrent ICSI implantation failure, increase in pregnancy rate.

DOI

10.21608/ejhm.2019.30105

Keywords

sildenafil, Implantation Rate, Recurrent ICSI failure

Authors

First Name

Yahia A.

Last Name

Wafa

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt

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First Name

Mohammed Moh.

Last Name

ALKhouly

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt

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Orcid

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First Name

Reham M. Salah Abdelsalam

Last Name

Mosalam

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Al-Azhar University, Cairo, Egypt

Email

dr_rehamsalah@yahoo.com

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Orcid

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Volume

75

Article Issue

2

Related Issue

5203

Issue Date

2019-04-01

Receive Date

2019-04-14

Publish Date

2019-04-01

Page Start

2,173

Page End

2,182

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_30105.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=30105

Order

9

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Low Dose Sildenafil in Improvement of Implantation Rate in Case of Recurrent ICSI failure

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Article

Created At

22 Jan 2023