Background: endometriosis is one of the most challenging diseases that constitute 20%-40% of women searching for their infertility diagnosis. The effects of endometriosis on assisted reproductive outcomes are the issues continuously debated. Aim of the work: This study was undertaken to compare the outcome of intracytoplasmic sperm injection (ICSI) in women with endometriosis and women with tubal factor infertility as controls. Patients and Methods: from 2016 to 2018 a retrospective study was carried out on patients with endometriosis (n=40) and tubal infertility (n=40) after treatment with ICSI. The main outcome measures were implantation rate, chemical and clinical pregnancy rates while secondary outcomes were COH, such as dosage and duration of gonadotropins, the number of oocytes retrieved, endometrial thickness and E2 level on the day of hCG, fertilization rate and the number of transferred embryos. Results: no statistically significant difference between the two groups in percentage of metaphase II oocyte, number of embryo transferred, implantation rate and chemical and clinical pregnancy rates, suggesting that embryo quality and uterine receptivity remains unaffected despite the number of oocyte retrieved and fertilization rate were significantly lower in endometriosis group. Conclusion: our data suggest that the presence of endometriosis in patients undergoing ICSI does not affect pregnancy outcome, although significantly fewer oocytes retrieved from patients with endometriosis, and lower fertilization rate.