Background: Gestational diabetes is one of the most common medical condition during pregnancy and its early detection is necessary to prevent prenatal and maternal complications. There is a link between raised CRP and development of gestational diabetes, so early detection of raised CRP may avoid serious maternal and neonatal hazards. Objective: The goal of this study was to detect the prevalence of raised high sensitivity C‑ reactive protein (hs‑ CRP) in normal pregnancy and gestational diabetes mellitus (GDM) and to compare the prevalence in both groups. Materials and methods: A case–control study was conducted between April 2018 and December 2018. A number of 60 pregnant women who were investigated for oral glucose tolerance test at 24–28 weeks of gestation were enrolled in this study. They were divided into 30 women with GDM as cases and 30 normal pregnant as control. They were investigated for the level of hs‑ CRP. Results: The prevalence of elevated hs‑ CRP in controls was 60%, whereas in cases it was 83.3%, with a P = 0.045 which is significant in this study.Conclusion: The study showed a raised level of hs‑ CRP in GDM in comparison with normal pregnant subjects.