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28682

Study of Serum Betatrophin Level in The Patients of Type 2 Diabetes Mellitus

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Last updated: 24 Dec 2024

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Abstract

Background: Type 2 DM is due primarily to lifestyle and genetic factors. A number of lifestyle factors are known to be important to the development of type 2 DM. Betatrophin, also known as angiopoietin-like protein (ANGPTL8), is a circulating protein predominantly produced in the liver and adipose tissue. Betatrophin is induced as a result of insulin resistance. It is reported to modulate pancreatic β-cell mass and glucose homeostasis reflectable on lipid metabolism.
Aim of the Study: Evaluation of the role of betatrophin in patients with type 2 diabetes mellitus.
Patients and Methods: This clinical study was carried out at Clinical Pathology Department, Tanta University Hospital and included 80 subjects who were divided into two groups: Group 1:40 Patients diagnosed with type 2 diabetes mellitus. Group 2: 40 normal subjects with matched age and sex as a control group.
Results: In type 2 diabetes mellitus patients group, serum betatrophin ranged from 25.83 to 860.65 ng/l with a median value of 54.815 ng/l while in control group, betatrophin ranged from 7.5-53.2 ng/l with a madian value of 11.250 ng/l. There was significant statistical difference in betatrophin between the two groups. (P < 0.001). Betatrophin was significantly higher in type 2 diabtes mellitus patients as compared to control group. Conclusion: Circulating betatrophine concentrations were significantly increased in patients with T2 DM and associated with glucose homeostasis and insulin sensitivity. Thus, the level of serum betatrophin has a potential role in detection and pathogenesis of T2DM.

DOI

10.21608/ejhm.2019.28682

Keywords

betatrophine, Type 2 diabetes mellitus

Authors

First Name

Aliaa H.

Last Name

El-Ghandour

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Tanta University

Email

your.dr012@gmail.com

City

-

Orcid

-

First Name

Aml S.

Last Name

El-Bendary

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Tanta University

Email

-

City

-

Orcid

-

First Name

Abeer A.

Last Name

Shahba

MiddleName

-

Affiliation

Department of Internal Medicine Faculty of Medicine, Tanta University

Email

-

City

-

Orcid

-

First Name

Ghada A.

Last Name

Soliman

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Tanta University

Email

-

City

-

Orcid

-

Volume

74

Article Issue

8

Related Issue

5084

Issue Date

2019-01-01

Receive Date

2019-03-13

Publish Date

2019-01-01

Page Start

1,809

Page End

1,816

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 74_Issue 8_Pages 1809-1816.pdf

PDF . 392.6kB

Link

https://ejhm.journals.ekb.eg/article_28682.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=28682

Order

17

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of Serum Betatrophin Level in The Patients of Type 2 Diabetes Mellitus

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Article

Created At

22 Jan 2023