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28679

Comparative Study between Metformin and Insulin in Controlling Gestational Diabetes Mellitus

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Last updated: 03 Jan 2025

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Abstract

Background: the use of antidiabetic drugs to control gestational diabetes was controversial. Some studies suggest a possible link between the use of oral antidiadetics and fetal anomalies, fetal macrosomia and neonatal hypoglycemia whereas others have demonstrated no such relationship.
Objective: This study aims to assess the efficacy of metformin in controlling maternal blood glucose level compared to insulin in women with GDM.
Patients and Methods: The present study included 116 pregnant women who have been diagnosed as gestational diabetics before 34 weeks gestation with singleton pregnancy. They had FBG level ranging from 90- 169 mg/ dl or 2-hour postprandial blood glucose level ranging from 110-176 mg/dl. The exclusion criteria include pregnant women with preexisting DM and underlying diseases known to affect fetal growth, preeclampsia, unbalanced chronic disease, twin pregnancy, or refused to participate.
Results: Comparison of the baseline characteristics was performed between 2 groups and there were no significant differences between the two groups regarding maternal age, gravidity, parity, GA at time of diagnosis, GA at beginning of treatment, and BMI at time of diagnosis. Analysis of the results revealed that metformin was an effective medication for control of euglycemic with diet only.

DOI

10.21608/ejhm.2019.28679

Keywords

Gestational diabetes mellitus, Metformin, metformin in gestational diabetes

Authors

First Name

Ehab Hassanin

Last Name

Mohamad

MiddleName

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Affiliation

Departments of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University

Email

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City

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Orcid

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First Name

Abdel Monsef Abdel Hamed

Last Name

Sedek

MiddleName

-

Affiliation

Departments of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

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First Name

Ahmed Fathy

Last Name

Abdel Aziz

MiddleName

-

Affiliation

Departments of Clinical Pathology, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Hisham Adel

Last Name

Abo Elez

MiddleName

-

Affiliation

Departments of Obstetrics & Gynecology, Faculty of Medicine, Al-Azhar University

Email

drhishamez@gmail.com

City

-

Orcid

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Volume

74

Article Issue

8

Related Issue

5084

Issue Date

2019-01-01

Receive Date

2019-03-13

Publish Date

2019-01-01

Page Start

1,791

Page End

1,798

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 74_Issue 8_Pages 1791-1798.pdf

PDF . 452.2kB

Link

https://ejhm.journals.ekb.eg/article_28679.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=28679

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparative Study between Metformin and Insulin in Controlling Gestational Diabetes Mellitus

Details

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Article

Created At

22 Jan 2023