Background: the modes of failure of total knee replacement(TKR) can be classified as intra-articular or extraarticular, as biological or mechanical, as early or late. Aseptic loosening is one of leading cause of failure of total knee replacement. Purpose: it was to spot light on different surgical strategies; to assess the results of 20 cases of revision total knee arthroplasty after aseptic loosening of primary total knee arthroplasty. Materials and Methods: this is a prospective interventional study which was conducted during the period from June 2016 to April 2019 with mean follow up two years. It included 20 patients (20 knees) which were undergone for revision TKR due to aseptic loosening of knee prosthesis. These cases were operated at Al-Azhar University hospitals (Al Hussein & Bab El Shaeria). Results: the average knee society score (KSS) was 79 (range from 55 to 94) compared with an average preoperative KSS of 38 (range from 28 to 48). The mean knee function score at the last follow up was 72 (range from 35 to 95) compared with the mean preoperative knee function score of 31 (range from 10 to 55). Conclusions: results of revision TKA due to polyethelene (PE) wear and its resultant osteolysis were mostly satisfactory to the patients