Background: Microparticles are found in all body fluids including peripheral blood. They play an important role in blood clot formation and increased cell aggregation. Aim of this work: Was to evaluate the level of circulating platelet microparticles (PMP) and tissue factor microparticles (TFMP) in Behcet`s disease and to assess the relation of these procoagulant markers and Behçet's disease activity. Patients and methods: This study included 100 persons divided to three groups; Behçet's disease (BD) group (40) patients, systemic lupus (SLE) group (40) patients as a comparative and control group (20) persons. Platelet-free plasma was ultra-centrifuged. PMPs and TFMPs were identified and enumerated with flow cytometry using anti CD61PE and CD142Percp antibodies. D-dimer was measured by ELISA. Results: There was statistically significant increase of PMP (CD61), tissue factor MP (CD142), CD61-MFI and CD142-MFI in Behcet`s group in comparison to Control group (p˂0.001). There was statistically significant increase of PMP and tissue factor MP in Behcet`s when compared to Lupus group (p˂0.001), while CD61/CD142, CD61- MFI and CD142-MFI revealed no significant difference. D-dimer was significantly increased during Behcet`s and SLE disease activity (p=0.036 & p=0.021 respectively). Active Behcet`s disease had significant increase of both CD61 and tissue factor expressing PMP (CD61/CD142) when compared to patients with inactive state (p˂0.001 & p=0.004 respectively), while CD142 showed no significant difference (p=0.38). In Behcet`s group, there was significant positive correlation between CD61 and each of CD61/CD142 and D-dimer (p=0.001). Conclusion: PMP and TF MP are significantly elevated in BD in comparison to SLE. PMP, PMP expressing TF and D-dimer are markers of disease activity in both BD and SLE, while ESR and CRP are not. PMP is positively correlated to TF expressing PMP and D-dimer in BD denoting enhanced prothrombotic state. PMP, PMP expressing TF and D-dimer are characters of ANCA positive BD.