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27413

Galectin-3 and Severity of The Coronary Artery Disease in Ischemic Patients Guided by Coronary Angiography

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Last updated: 30 Jan 2023

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Abstract

Background: The inflammatory process is actively involved in atherosclerosis and underlies all stages of atherosclerotic plaque development: the beginning, the progression and the plaque rupture. It has been reported that during the inflammatory process the expression of Gal-3 is increased in human atherosclerotic lesions, suggesting its involvement in atherogenesis. Aim: In the present study, we tried to evaluate the levels of Gal-3 in patients with chronic stable angina and its relation to the severity of coronary artery disease (CAD) and the CAD risk factors such as Aging, Diabetes, Hypertension, Smoking and Dyslipidemia. Patients and Methods: Our study population consisted of 95 chronic stable angina patients who were planned for coronary angiography. All patients had clinical and/or electrocardiographic evidence of significant stable ischemic heart disease.
Results: We found a significant positive correlation between CAD and Gal-3 levels (r = 0.207), (p value= 0.045). Patients with multi-vessel (MVD) had significantly higher plasma Gal-3 levels and syntax score than 3 vessel disease (TVD) and single vessel disease (SVD) (P value <0.001)., while Patients with TVD had significantly higher plasma Gal-3 levels and syntax score than SVD, but still lower than MVD Patients (P value <0.001. Conclusion: Gal-3 plasma levels were significantly correlated with the severity of CAD in chronic stable angina and can be used as a prognostic marker of chronic stable angina patients.
Recommendation: We recommend that the Gal-3 might be useful for risk stratification and outcome prediction of coronary heart diseases.

DOI

10.21608/ejhm.2019.27413

Keywords

Coronary Artery Disease, SYNTAX score, chronic stable angina

Authors

First Name

Reda Biomy

Last Name

Bastawesy

MiddleName

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Affiliation

Faculty of Medicine, Department of cardiology Kafr El Sheikh University

Email

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City

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Orcid

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First Name

Mohamed Kamal

Last Name

Salama

MiddleName

-

Affiliation

Faculty of Medicine, Department of cardiology, Aswan University

Email

-

City

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Orcid

-

First Name

Hossam Eldin Mohamed

Last Name

Mansour

MiddleName

-

Affiliation

Faculty of Medicine, Department of cardiology, Aswan University

Email

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City

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Orcid

-

First Name

Ahmed Barakat

Last Name

Ahmed

MiddleName

-

Affiliation

Faculty of Medicine, Department of cardiology, Aswan University

Email

ahmed8930ahmed@gmail.com

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-

Orcid

-

Volume

74

Article Issue

6

Related Issue

4763

Issue Date

2019-01-01

Receive Date

2019-02-18

Publish Date

2019-01-01

Page Start

1,371

Page End

1,376

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 74_Issue 6_Pages 1371-1376.pdf

PDF . 482.7kB

Link

https://ejhm.journals.ekb.eg/article_27413.html

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https://ejhm.journals.ekb.eg/service?article_code=27413

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22

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023