Background: COPD exacerbations necessitating mechanical ventilation representing important aspect of disease management. Attempts to search for better weaning index is a continuous process. Aim of the work: was to study the accuracy of the integrated weaning indices including, CROP index and CORE index as predictors of weaning success in COPD exacerbation under mechanical ventilation. Patients and Methods: 102 COPD patients necessitating mechanical ventilation >24 h underwent daily screen of subjective and objective indices for weaning readiness, and patients were classified according to weaning outcome into successful group (Group S) (60 patients) and failure group (Group F) (42 patients). Results: There were no significant observed difference regarding the demographic data between the successful and the failure groups. There was highly significant difference between both weaning groups regarding dynamic compliance, NIF, P0.1, CROP index and CORE index (P value < 0.05). AUC of CROP index (0.80) was moderately precise compared with that of CORE index (0.63). Conclusion: CROP index is superior to CORE index as a predictor of weaning success in mechanically ventilated COPD patients