Background: Gastrointestinal (GI) bleeding is a potentially life threatening abdominal emergency that remains a common cause of hospitalization. Bleeding from the upper gastrointestinal tract is approximately five times more common than from the lower gastrointestinal tract bleeding and seems to be more common in men and the elderly. Aim: Identify various cause and outcomes of upper gastrointestinal tract bleeding patients in Aswan University Hospital by follow-up the patients and their different fates on the numerous lines of treatment. Methodology: This study included 100 patients who were complaining of upper gastrointestinal tract bleeding and selected from patients in Aswan University Hospitals. Results: The results of the current study showed that the most common causes of upper GIT bleeding are the variceal causes representing 57% of causes of GIT bleeding, followed by non-variceal causes representing 43% of causes of GIT bleeding. The most common cause of the variceal bleeding is the esophageal varices alone representing (40%) of the causes of variceal bleeding followed by combined esophageal and gastric varices representing (12%) and the gastric varices alone representing (5%) of the causes of upper GIT bleeding. Conclusion: The endoscopic therapy was successful in most cases. The recurrence rate of bleeding was significantly high among patients with variceal bleeding. The patients with variceal bleeding have fewer treatmentrelated complications and better survival rates when they are treated by band ligation