Background: Preeclampsiais a leading cause of both maternal and prenatal morbidity and mortality worldwide. Preeclampsia is more common in developing countries due to women's low dietary intake of essential minerals and vitamins, micronutrients such as copper, zinc, magnesium, manganese and selenium.
Aim of work: was to investigate the levels of serum zinc and copper in preeclamptic women versus normal pregnant women.
Patients and Methods: This case-control prospective study included a total of 50 pregnant women attending the Antenatal Clinic, Department of Obstetrics and Gynecology, Al-Azhar University Hospital.  Subjects were categorized into 2 groups. Group I:25 women with preeclampsia and Group II:25 normal pregnant women without preeclampsia who served as controls. Studied group women were subjected to the following investigations: Urine analysis for detection of albumin and measurement of the degree of proteinuria, CBC, liver function tests, renal function tests, coagulation profiles and serum zinc and copper estimation were done. Results: have showed that preeclamptic pregnant women have low serum concentration of zinc (Zn) and copper (Cu) comparing to the healthy pregnant women. Zinc levels in control group was 95.7 mg/dL and in preeclamptic group 60.8 mg/dL with highly significance statistical difference (p<0.001). Copper levels in control group was 96.7mg/dL  and in preeclamptic group 62.9 mg/dL with highly significance statistical difference (p<0.001).
Concusion:  It could be concluded thatthere are certain circumstances where preeclamptic pregnant women have low serum concentration of zinc (Zn) and copper (Cu) than the healthy pregnant women. This suggests the possible involvement of depleted serum trace element in the pathogenesis of preeclampsia, but we could not tell if this decrease in serum levels of Zn and Cu was a cause or a result of preeclampsia.