Background: Inguinal hernias are one of the most common problems encountered by the surgeon, accounting for about 10-12% of all operations. Operations for the inguinal hernia are one of the most common procedures. Currently herniorrhaphy is the most performed surgical procedure in the world. Aim: The aim of this study is to compare tissue adhesives and how it can reduce postoperative complications, especially chronic pain as well as recurrence rate in self-gripping mesh compared with sutured mesh in open inguinal hernia repair. Methods: This study conducted on 30 cases of fresh inguinal hernia submitted to inguinal hernioplasty "mesh repair" 15 of them submitted to sutureless mesh "Group I" while the other 15 cases submitted to sutured mesh "Group II". Results: Our results revealed that there was no statistical difference between both groups regarding the age. Also, there was no significant difference between both groups regarding gender. Our study revealed that the operative time was longer and blood loss was more during operation in sutured group than in sutureless group. In spite of increase incidence of complications sutured group than in sutureless in our study but there was no difference between both groups regarding complications. Conclusion: From our study we can conclude that the use of self-grip (sutureless) meshes and sutured meshes in the management of groin hernias have nearly the same results in experienced hands.