Background: Laparoscopic cholecystectomy is standard procedure for management of gallbladder stone. Gallstones (cholelithiasis) are the most common cause of biliary tract disease in adults. The educative role of nurse is integral part of the care that is essential to patient satisfaction and positive outcomes. Objective:Identify health needs of patients with cholelithiasis who were undergoing laparoscopic cholecystectomy. Patients and Methods:  A  convenient  sample  of  100  adult  patients  with  cholelithiasis  who were  undergoing laparoscopic cholecystectomy. Health needs of patients with cholelithiasis who were undergoing laparoscopic cholecystectomy included structured interview schedule was used to collect the data for the present study. It included two parts about socio-demographic and clinical data, knowledge related to nature of the disease, pre- operative preparation, post-operative care and self- care following discharge. Results:the present study revealed that the majority of the studied patients had poor level of knowledge. There was statistically significant positive correlation between patients' level of knowledge and age, educational level, nurses as a source of knowledge and advices as well as physician and the nurse as a preferred source of knowledge. Conclusion:It was concluded that the studied patients had poor level of knowledge regarding disease nature, pre-operative care, post-operative care and complications and self-care following discharge.