Background: Healing of wounds is considered as a complex and dynamic process, Platelets play an important role in the process of wound healing because it releases many growth factors that may be valuable in improving the results of the healing process. Aim of the Work: The purpose of this study was to evaluate the effect of autologus plasma injection in the wound site immediately after wound closure on the process of wound healing. Patients and Methods: The study was conducted on  60 patients having wounds at different sites of the body either post-traumatic or post-operative. They were grouped into two groups: Group A received autologus plasma injection in the wound site immediately after primary wound closure together with the usual wound care while the other group B received only the usual wound care without plasma injection. We have evaluated the wound healing process parameters as vascularity, pigmentation, pliability, pain, stiffness, the cosmetic results and development of complications using the Patient And Observer Scar Assessment Scale (POSAS) Score.  Results: We have found that the results of the wound healing process have improved much in group A which received autologus plasma injection than that was found in group B that didn't receive plasma injection regarding vascularity, pigmentation, pliability, pain, wound healing complications, cosmetic results and patients' satisfaction. Conclusion: Autologus plasma injection in the wound site immediately after wound closure has enhanced the wound healing process, gave better cosmetic results and led to more patients' satisfacion because it contains abundant growth factors, cytokines and biologically active substances.