Background: the syndrome of polycystic ovary syndrome (PCOS) is clinically and biochemically heterogeneous. Medical treatment of PCOS is tailored to the patient's goals. Broadly, these may be considered fewer than four categories: lowering of insulin levels, restoration of fertility, treatment of hirsutism acne and restoration of regular menstruation. Objective: this study aimed to study the effect of Metformin alone after laparoscopic ovarian drilling on ovulation in women with clomiphene citrate resistant polycystic ovary syndrome in comparison with studying the effect of Metformin with Dexamethasone after laparoscopic ovarian drilling on ovulation in women with clomiphene citrate resistant polycystic ovary syndrome. Methodology: in the present study, 60 patients with PCO were resistant to clomiphene citrate therapy had undergone ovarian drilling. Those patients had been classified into 2 groups according to the selected therapy. Two trails had been compared; group A received metformin (850 mg twice daily) plus dexamethasone (2mg daily from day 5 to day 14 monthly) for 3 months while group B had received metformin only (850 mg twice daily). Results: our study showed no significant correlation between serum progesterone level after therapy and different parameters in both study groups. Conclusion: we concluded that there was a good value of administration of Dexamethasone with Metformin after laparoscopic ovarian drilling in patients with clomiphene resistant polycystic ovarian disease especially those patients with normal DHEAS levels.