Aim: to assess the prevalence of female sexual dysfunction among women of Damietta governorate Patients and methods: 500 randomly selected sexually active non-pregnant married women at age 18 – 45 years from outpatient clinics of Al-Azhar University Hospital were subjected to filling out the Arabic validated FSFI. Results: The frequency of female sexual dysfunction among women of Damietta Governorate was 62% of participants. There was a statistically significant difference between women with female sexual dysfunction (FSD) and women without FSD in age, age of marriage and education level (P<.0001). Also, women not working were at higher risk to get FSD (P<.001) with the significant impact of socioeconomic level on having FSD. Also, we reported a statistically significant difference between women with FSD and women without FSD in the mode of delivery and women used IUD &72.6% had a history of circumcision. There was a statistically significant difference between women with FSD vs women without in mean score of desire, arousal, lubrication, orgasm, satisfaction, and pain as women with FSD showed less score in all domains compared to women without the disease. Conclusion: FSD was a significant health problem in Damietta that needs to be investigated more deeply and assessing associated risk factors. Low rate of overt complaints regarding sexual problems among Egyptian women does not indicate lack of sexual interest but reflects cultural factors such as shyness, embarrassment, reluctances of the women and lack of physicians' awareness which lead to inadequate identification and management of such problems.