Background: ficolin-2 is a kind of human serum complement lectin with a structure similar to mannan-binding lectin (MBL) and it has been implicated in innate immunity. Recent studies have shown that complement pathway activation may contribute to hepatitis. However, the relationship between ficolin-2 and viral hepatitis remains largely elusive. Aim of the work: this study aimed to determine the dynamics of ficolin-2 in patients with chronic hepatitis C. Patients and Methods: Thirty patients who had not yet received therapy and twenty normal control subjects were included in this study. A sandwich enzyme-linked immunosorbent assay (ELISA) was used to measure the ficolin-2 concentrations in all serum samples of patients and 20 healthy donors. Results: we found that the concentrations of ficolin-2 were significantly higher in chronic hepatitis C patients with abnormal ALT values than in chronic hepatitis C patients with normal ALT values and healthy controls. Ficolin-2 concentrations in chronic hepatitis C patients with abnormal ALT values were positively correlated with ALT levels (*P <0.05). Then, we found ficolin-2 concentrations in rapid viral response (RVR) group decreased significantly (*P <0.05), while in non-RVR group, ficolin-2 decreased slightly (P >0.05). Conclusion: our findings suggested that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response.