Background: Age-related Macular Degeneration (AMD) is a progressive, degenerative disease that affects the macula and it is one of the most common leading causes of irreversible vision loss in old patients with age more than fifty. Optical coherence tomography angiography (OCTA) can detect the presence of choroidal neovascularization (CNV), structural changes in AMD; moreover, changes in choroidal blood vessel flow. Aim: to assess and compare structural retinal changes in patients with neovascular age-related macular degeneration (AMD) treated with 2mg/0.1ml intravitreal aflibercept three times with an interval of one month each. Patients and methods: twenty eyes of non-diabetic non-hypertensive ARMD patients were included. They received 2mg/0.1ml intravitreal aflibercept three times with an interval of one month each. OCTA was done before the first injection and was repeated one month after the third injection. Results: the area size and the GLD of the CNV had highly statistically significantly improved after 2mg/0.1ml three intravitreal aflibercept injections. Conclusion: aflibercept is an effective treatment in AMD; it can decrease the area size, GLD, and thickness of the CNV. OCTA is an effective tool that can provide a noninvasive method in the diagnosis and follow up of the activity and anatomical changes in AMD.