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20458

Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hep

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Last updated: 03 Jan 2025

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Abstract

Introduction: for SNP, the CC is associated with a higher SVR after DAAs/RBV therapy while, the genotype TT is a risk factor for non-response. Aim of the work: this study aimed to assess the value of SNP (rs8o99917) as a predictor of SVR. Methodology: this study was a retrospective controlled study and was performed on a total number of 15o patients who were treated by DAAs/RBV for 12 weeks and SNP was done for the all the patients. Results: CC genotype was more prevalent in SVR group than CT and TT genotypes. Conclusion: determination of SNP before starting antiviral therapy may serve as a good response predictor.

DOI

10.21608/ejhm.2018.20458

Keywords

HCV-direct acting antiviral drugs, interleukin 28b SNP

Authors

First Name

Mahmoud Mohammad Moussa

Last Name

Bazeed

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

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Orcid

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First Name

Anwar Gomaa

Last Name

Elsheety

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

Email

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Orcid

-

First Name

Mohammad Saied

Last Name

Bakeer

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

Email

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City

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Orcid

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First Name

Mohamed Ali

Last Name

Saber

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

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City

-

Orcid

-

First Name

Essam Abdel Nabi

Last Name

Mohammady

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, Al-Azhar University

Email

tantawy_wael@yahoo.com

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-

Orcid

-

Volume

73

Article Issue

10

Related Issue

4006

Issue Date

2018-10-01

Receive Date

2018-12-04

Publish Date

2018-10-01

Page Start

7,842

Page End

7,849

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 73_Issue 10_Pages 7842-7849.pdf

PDF . 556.1kB

Link

https://ejhm.journals.ekb.eg/article_20458.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=20458

Order

30

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparison between clinical and biochemical versus interleukin 28B as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis C virus patients

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Type

Article

Created At

22 Jan 2023