Background: cervical carcinoma is one of the commonest female tumors worldwide arises from cervical intraepithelial neoplasia. Cervical cancer is a multifactorial process and infection with some types of human papilloma virus (HPV) has been suggested as the most important risk factor. The genesis of cancer was correlated with abnormal regulation of DNA damage and repair. A research proved that CDK5 was mandatory for the DNA damage response in cancer cells. Ki-67 is a nuclear protein that is associated with RNA transcription and cell cycle progression. Aim of the work: the purpose of this study was to evaluate the expression of CDK5 in cervical precancerous lesions and carcinoma to clarify its role in carcinogenesis and progression of cervical cancer, as well as the expression of Ki-67. Material and Method: specimens included (55 cases) consisted of precancerous lesions (15), SCC (30), adenocarcinoma (10). All specimens were formalin-fixed and embedded in paraffin blocks. Multiple serial 5-microne thick sections were cut from the paraffin blocks of the specimens; one was stained by Hematoxylin and Eosin for histopathological examination, Other Sections were immunostained with antibodies to CDK5 and K-i67. Results: high tumor grade and high FIGO stage were positively correlated with CDK5 IHC expression (P-value=0.012 and 0.042) and with Ki67 IHC expression (p-value= 0.01 7and 0.044) respectively. Conclusion: there is a direct positive correlation between both CDK5 and Ki-67 expression with high tumor grade and high FIGO stage of cervical carcinoma.