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18941

Histochemical studies on the role of pantothenic acid on radiation damage of the kidney

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Last updated: 03 Jan 2025

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Abstract

The present study was designed to evaluate effect of pantothenic acid to gamma irradiated rats. Female albino rats (120-150gm) were subjected to (5 Gy) whole body 137Cs gamma irradiation. Fresh kidney specimens were obtained after 1 and 4 weeks of treatment. Frozen sections were prepared for histochemical study for localization of both acid, alkaline phosphatases and succinic dehydrogenase enzymes. The enzymatic activity was quantitatively evaluated and statistically analyzed. The obtained results showed significant decrease in both alkaline phosphatase and succinic dehydrogenase enzymes activity while the acid phosphatase enzyme activity was significantly increased in comparison to the control group after one week, while after four weeks the activity of both acid and alkaline phosphatase were significantly increased, while the enzymatic activity of succinic dehydrogenase decrease.
Pantothenic acid treatment (22 mg/kg body weight / day for 6 days) after half hour of radiation showed marked improvement of the radiation induced changes in the activity of measured enzymes.
Finally it could be concluded that pantothenic acid could be of value in improving the radiation injury on the kidney.

DOI

10.21608/ejhm.2001.18941

Authors

First Name

Omaima S.

Last Name

Eissa

MiddleName

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Affiliation

National Centre for Radiation Research and Technology

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First Name

Ashraf M.

Last Name

Moustafa

MiddleName

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Affiliation

Histology Dept., Faculty of Medicine, AL-Azhar University, Cairo, Egypt

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Volume

2

Article Issue

1

Related Issue

3895

Issue Date

2001-01-01

Receive Date

2018-11-13

Publish Date

2001-01-01

Page Start

163

Page End

180

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 2_Issue 1_Pages 163-180.pdf

PDF . 960.3kB

Link

https://ejhm.journals.ekb.eg/article_18941.html

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https://ejhm.journals.ekb.eg/service?article_code=18941

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Histochemical studies on the role of pantothenic acid on radiation damage of the kidney

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Article

Created At

22 Jan 2023