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18916

Rocuronium bromide: a pharmacological study

Article

Last updated: 03 Jan 2025

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Abstract

This work was designed to assess the pharmacological effects of rocuronium. In either isolated preparation or intact animals. Rocuronium (6-96 μg/ml) caused a significant dose related reduction in the amplitude of rat phrenic nerve diaphragm contraction in response to indirect stimulation, the mean percentage reduction were statistically significant. The addition of neostgmine (0.25 μg/ml) caused complete reversal of the relaxant effect of rocuronium . In intact cat gastrocnemius sciatic nerve preparation rocuronium (25 - 200 μg/kg) caused dose dependent statiscally significant reduction. In comparing the drug with succinyl choline by the head drop method the mean time in second was 15.34 ±1.57 and 10.44 ±0.91 respectively.

DOI

10.21608/ejhm.2001.18916

Authors

First Name

Maaly M.H

Last Name

Gaafary

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Affiliation

Department of Anaesthesiology, Faculty of Medicine For Girls Al-Azhar University.

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Orcid

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First Name

Essam F.

Last Name

Al. Alkami

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Affiliation

Department of Pharmacology, Faculty of Medicine, Cairo University.

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Volume

2

Article Issue

1

Related Issue

3895

Issue Date

2001-01-01

Receive Date

2018-11-13

Publish Date

2001-01-01

Page Start

1

Page End

10

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 2_Issue 1_Pages 1-10.pdf

PDF . 1.2MB

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https://ejhm.journals.ekb.eg/article_18916.html

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https://ejhm.journals.ekb.eg/service?article_code=18916

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Rocuronium bromide: a pharmacological study

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Article

Created At

22 Jan 2023