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Protective Effect Of Melatonin, Methionine And Zink On Cadmium Nephrotoxicity: Histopathologically, Histochemically And AgNORs Quantitation

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Last updated: 03 Jan 2025

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Abstract

Cadmium (Cd) is a highly toxic heavy metal that is naturally present in the environment. Chronic exposure to Cd causes hepatotoxicity and nephrotoxicity. The present study aimed to study the protective effect of melatonin, methionine and zinc against histopathological, histochemical and proliferative effects of cadmium on the kidney of rats. A total of 80 female albino rats were included in this study and divided into 8 groups. They were injected intraperitonealy with cadmium chloride (CdCl2) (2 mg / kg b.w.), melatonin (10 mg / kg b.w.), methionine (42.8 mg / b.w.) or zinc (20 mg / kg b.w.) with or without CdCl2 daily for 10 days. Treatment with CdCl2 induced marked tubular cell degeneration with large areas of interstitial hemorrhage.There were marked destruction of the brush borders with decrease in glycogen and protein contents of the degenerated tubules. AgNORs count significantly increased. Injection of melatonin or methionine to CdCl2 treated rats resulted in improvement of Cd-induced histopathological and histochemical changes. AgNORs count significantly decreased. Zinc injection partially protected the kidney from Cd-induced effects. In conclusion, melatonin and methionine have a more protective effect than zink against Cd nephrotoxicity.

DOI

10.21608/ejhm.2001.18908

Authors

First Name

Sonia L.

Last Name

El Sharkawy

MiddleName

-

Affiliation

The Basic Medical Sciences Department, Pathology Researches, National Research Center

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Orcid

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First Name

Hafiza A.

Last Name

sharaf

MiddleName

-

Affiliation

The Basic Medical Sciences Department, Pathology Researches, National Research Center

Email

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City

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Orcid

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First Name

Nabila S.

Last Name

Hassan.

MiddleName

-

Affiliation

The Basic Medical Sciences Department, Pathology Researches, National Research Center

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City

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Orcid

-

Volume

3

Article Issue

1

Related Issue

3894

Issue Date

2001-04-01

Receive Date

2018-11-13

Publish Date

2001-04-01

Page Start

141

Page End

160

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 3_Issue 1_Pages 141-160.pdf

PDF . 717.8kB

Link

https://ejhm.journals.ekb.eg/article_18908.html

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https://ejhm.journals.ekb.eg/service?article_code=18908

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11

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Protective Effect Of Melatonin, Methionine And Zink On Cadmium Nephrotoxicity: Histopathologically, Histochemically And AgNORs Quantitation

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Article

Created At

22 Jan 2023