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18902

Study Of The Relation Between Helicobacter Pylori Infection And Gastric Interleukin (8) In Patients With Chronic Liver Disease

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Last updated: 03 Jan 2025

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Abstract

Helicobacter pylori (H pylori) is a gram negative spirally shaped bacterium. It is known to be the most common important cause of gastritis, peptic ulcer, non ulcer dyspepsia and gastric carcinoma. The frequency and importance of gastric mucosal lesion in patients with chronic liver disease (CLD) have been increasingly recognized in recent years. IL-8 a potent leukocyte chemoā€“attractant cytokine produced by H pylori. It promotes polymorphnuclear leucocytes (PMNs) and mononuclear cells (MNCs) accumulation in gastric mucosa.This work aimed to clarify the relation between H pylori and IL-8 production in various chronic liver disease (CLD) lesions. Eighty patients were included in this study, 50 with CLD and 30 dyspeptic patients without CLD. Gastric mucosal biopsies were examined histopathologically for H pylori, cellular infiltration and associated pathology, together with culture of H pylori and assessment of IL-8 level in gastric tissue supernatant. 30/50 (60%) CLD patients,10/15 (66.6%) patients with non gastric dyspepsia, and 14/15 (93.3%) patients with gastric dyspepsia were positive for H pylori. There was no relationship between the prevalence of H pylori and the aetiology of CLD. No significant difference was observed in CLD patients' group as regard to H pylori and Child grading, degree of varices, gastric or liver histopathology. Statistical difference in H pylori prevalence between patients with CLD and those with gastric dyspepsia was significant. IL-8 showed significant increase in H pylori positive vs H pylori negative patients. Positive correlation was found between H pylori density and tissue IL-8 and cellular infiltration. In conclusion the liver status does not play a role in the prevalence of H pylori infection, further studies to investigate the relation between virulent H pylori and IL-8 are needed.

DOI

10.21608/ejhm.2001.18902

Authors

First Name

Mohsen M

Last Name

El-Khayat

MiddleName

-

Affiliation

Tropical medicine departments, faculty of medicine-Menoufia University

Email

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Orcid

-

First Name

Zeinab N

Last Name

Said

MiddleName

-

Affiliation

Microbiology department, faculty of medicine (for girls) Al Azhar University

Email

-

City

-

Orcid

-

First Name

Gamal S

Last Name

El-Deeb

MiddleName

-

Affiliation

Tropical medicine departments, faculty of medicine-Menoufia University

Email

-

City

-

Orcid

-

First Name

Hany S

Last Name

Sabry

MiddleName

-

Affiliation

Tropical medicine departments, faculty of medicine-Menoufia University

Email

-

City

-

Orcid

-

First Name

Mamdoh M

Last Name

Radwan

MiddleName

-

Affiliation

pathology departments, faculty of medicine-Menoufia University

Email

-

City

-

Orcid

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Volume

3

Article Issue

1

Related Issue

3894

Issue Date

2001-04-01

Receive Date

2018-11-13

Publish Date

2001-04-01

Page Start

90

Page End

106

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 3_Issue 1_Pages 90-106.pdf

PDF . 446.9kB

Link

https://ejhm.journals.ekb.eg/article_18902.html

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https://ejhm.journals.ekb.eg/service?article_code=18902

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study Of The Relation Between Helicobacter Pylori Infection And Gastric Interleukin (8) In Patients With Chronic Liver Disease

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Article

Created At

22 Jan 2023