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18818

Histopathological and Biochemical Evaluation of the Pulmonary Toxicity of Cadmium Chloride and thiocarbamate

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Last updated: 30 Jan 2023

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Abstract

The aim of the present work is to study the acute pulmonary toxicity of cadmium chloride (CdCl) and diethyldithiocarbamate (DDTC) each separately and in  "#  $     %& '(( )  "%& '**+(),  - #    .    #  $ /! .0  . cadmium content in the blood and lung were measured by atomic absorption spectrophotometer. It was found that the blood cadmium concentration significantly   '12!),.  . "       However, with combined treatment the cadmium level in the lung showed significant   '1 2 !)  /   0    , #             !
Histopathological examination of the lung showed inflammatory infiltrate of alveolar septa specially around blood vessels in DDTC treated animals. While that were exposed to CdCl and to combined (CdCl + DDTC) showed interstitial fibrosis and chronic inflammation. These changes were more severe and serious with combined exposure. Moreover the electr  "   0"       !  of combined exposure showed damage of type I pneumocytes, hyperplasia of type II pneumocytes with loss of microvilli. While the interstitial tissue revealed collagen bundle and chronic inflammatory cells.

DOI

10.21608/ejhm.2002.18818

Authors

First Name

Somaya Y.M

Last Name

Hamoudah

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Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Medicine (for Girls) Al AL Azhar University

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Orcid

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First Name

Samia I.

Last Name

El Naggar

MiddleName

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Affiliation

Department of Pathology, Cairo University

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Orcid

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First Name

Haleem

Last Name

H.H

MiddleName

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Affiliation

Department of Biochemistry, Animal Health Research Institute Dokki

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Volume

7

Article Issue

1

Related Issue

3806

Issue Date

2002-04-01

Receive Date

2018-11-12

Publish Date

2002-04-01

Page Start

28

Page End

40

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 7_Issue 1_Pages 28-40.pdf

PDF . 681.1kB

Link

https://ejhm.journals.ekb.eg/article_18818.html

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https://ejhm.journals.ekb.eg/service?article_code=18818

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023