This study has been conducted to determine efficacy of conventional TENS on the autonomic function by assessing the big toe skin temperature (TST) and the motor conduction velocity (MCV) of the neuropathic tibial nerve. Thirty neuropathic patients (20 males, and 10 females) ranging in age from 30 to 50 years (X= 45.41±1.16) who were divided into 3 groups of equal number (two study and one control) and consented to receive 40 Hz and 80 Hz conventional TENS along the tibial nerve course for the first and second study groups respectively, while the third (control group) received placebo TENS. Both TST and MCV were recorded before and immediately after treatment (one session for 25 minutes). Treatment and data collection procedures were done in air conditioned room with the ambient room temperature was adjusted within the comfortable zone between 24ºC to 28ºC. Data collected showed a significant differences in both TST and MCV in meter/ second, in the first study group (P<0.05) and in the second study group (p<0.001). While there was no significant differences in the control group (p>0.05). There was a correlation between the TST and MCV in both study and control groups. The 80 Hz conventional TENS was more fruitful in enhancing the autonomic and electrophysiological functions of the neuropathic tibial nerve as manifested by the increased TST and MCV than 40Hz conventional TENS.