This work aimed to elucidate the protective action of panax ginseng roots against hazardous effects of thioacetamide{TA} intoxication .Oral administration of thioacetamide (300mg/kg)dissolved in drinking water for 12 weeks greatly affected liver and testis .This appeared from significant increase in serum alkaline phosphatase ,serum total acid phosphatase and serum prostate acid phosphatase . Previous starvation for 48 and 72 hrs immediately prior to TA administration strongly potentiated the effects of TA on the serum , testis and liver plasma membrane parameteres . The testis and liver damage may be one of the reasons of the cell death in TA intoxicated rat testis and liver. However, oral administration of Panax ginseng roots (117mg /kg.) for a period of 10 days prior to TA administration performed protective effect against TA toxicity. The obtained results showed that pre-treatment with Panax ginseng roots significantly modulated the changes in the physiological pathway induced by TA intoxication, and that Panax ginseng roots manifested marked improvement in the liver function and the structure of testis and epididymis. Also pre-treatment with ginseng caused a significant reduction in the deteriorated cells and this may support the protection against cellular damaging action.