We have studied the effect of cigarette smoke inhalation versus subcutanous nicotine injction on the liver of 40 adult male albino rats . Animals were divided into; cigarrete inhalation group and subcutaneous nicotine injection group. Inhalation group was subdivided into 5 subgroups ;three groups inhaled the smoke of two cigarettes three times a day in a closed chamber for 1,2&3 weeks respectively; a group of recovery after inhalation and a control group.The nicotine injection group was also subdivided into 5 subgroups;three groups were injected subcutaneously with 0.1ml of 1% nicotine every two days for 1,2&3 weeks respectively; a group of recovery after injection and a control group.Rats were sacrificed at the determined durations and the liver was subjected for preparation of 6 microns paraffin sections. Microscopic examination of paraffin sections stained with H&E; Masson trichrome and PASwas done and interpreted with the image analyzer. Several histological findings such as degenerative changes in hepatocytes, cellular infiltration, periportal fibrosis, and congestion of both central and portal veins have been noticed. Also, histochemical P.A.S. reaction has showed marked decrease in both groups. The mean optical density (O D) of P A S in hepatocytes of cigarette group was (0.31±0.02), and that of nicotine group was (0.26±0.03), which were significantly lower than that in the control group with mean O.D. (0.54±0.5) and (0.51±0.03) respectively. In conclusion; the inhalation of nicotine in the form of cigarette smoke resulted in deteriorative changes in the liver of the male adult albino rat more than nicotine injected subcutaneously, and these changes was partialy reversed shortly after withdrawal.