The present investigation deals with histopathological and histochemical studies of profenophos on liver and kidney of male albino rats and the protective effects of vitamin C and ginseng to reduce the deleterious effect induced by profenophos. Oral administration of profenophos at dose level of 1 /10 LD50 for 15 successive days induced histological changes in liver and kidney. No histological or histochemical change could be detected in liver and kidney of rats treated with each of vitamin C and ginseng. Profenophos treatment also resulted in histochemical changes in liver and kidney including decrease in protein granules and marked decrease in DNA and mucopolysaccharides content. Administration of vitamin C (0.01/ 100 g b.w) and ginseng (20 mg/ kg b.w) to profenophos treated animals resulted in an improvement in histological picture of liver and kidney as well as the histochemical parameters.