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18251

Evaluation of silymarin and / or ginger effect on induced hepatotoxicity by carbon tetrachloride in male albino rats

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Last updated: 03 Jan 2025

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Abstract

Liver disease appears to be increase. Part of this increase may be due to our frequent contact with chemicals and other environmental pollutants. The amount of medicne consumed has increased greatly which could be danger to the liver. The hepatoprotective flavonoid, silymarin (7.56 mg/Kg b. wt.) and ginger (Zingiber officinale) (1% of diet) for 4 weeks were used to ameliorate the liver injury in rats intoxicated with carbon tetrachloride (CCL4 , single acute dose 4 ml/ Kg b. wt. of 50% v/v CCL4 in olive oil, subcutaneous). The obtained results showed that CCL4 decreased serum and liver total protein and albumin. Also reduced glutathione content. The antioxidant enzymes; glutathione-S-transferase, superoxide dismutase and catalase activity decreased in the liver of CCL4 toxicity group. On the other hand, CCL4 toxicity increased serum and liver bilirubin, total lipid and total cholestertol levels. In addition, liver function (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and liver lipid peroxidation content showed significant increase in the CCL4 treated group. Previous parameters turned back to normal values in carbon tetrachloride intoxicated rats after treating with silymarin and/ or ginger for one month. Meanwhile, the most interesting effect was induced by a combination of silymarin and ginger. Hence, the present findings will provide a potential scope for future use of ginger for the treatment of liver disorders.  

DOI

10.21608/ejhm.2003.18251

Keywords

Silymarin-ginger-carbon tetracholoride-hepatotoxicity- rats

Authors

First Name

Hassan

Last Name

H. A

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Affiliation

Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt.

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First Name

EL-Gendy

Last Name

A. M

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Affiliation

Zoology Department, Faculty of Science (Girls), AL-Azhar Univfersity, Nasr City, Cairo, Egypt.

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Volume

12

Article Issue

1

Related Issue

3796

Issue Date

2003-04-01

Receive Date

2018-11-02

Publish Date

2003-04-01

Page Start

101

Page End

112

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 12_Issue 1_Pages 101-112.pdf

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https://ejhm.journals.ekb.eg/article_18251.html

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https://ejhm.journals.ekb.eg/service?article_code=18251

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12

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of silymarin and / or ginger effect on induced hepatotoxicity by carbon tetrachloride in male albino rats

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Article

Created At

22 Jan 2023