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18235

Influence of ionizing radiation on Cobra (Naja haje) and Cerastes cerastes venoms: Toxicological and immunological aspects.

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Last updated: 30 Jan 2023

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Abstract

The effect of gamma irradiation (15 KGy) on the Cobra Naja haje and Cerastes cerastes venoms toxicity and immunogenicity was evaluated. Irradiated venoms were at least 28.1% less toxic than non-irradiated venoms. However the antigenic response was not changed as judged by the capacity of irradiated venoms to react with polyvalent antivenom horse serum. The immunodiffusion method showed identity between irradiated and non-irradiated samples. The effect of gamma radiation on some venom enzymes and venoms profile was studied. Proteolytic, phospholipase A2 and hemorrhagic activities were inhibited by irradiation. Irradiation with gamma rays resulted in structural changes in the venoms as indicated by the changes in their molecular weights. The results indicated that irradiation of toxic protein -using suitable dose- can promote significant detoxification but still retaining many of the original antigenic and immuonological properties of native venom.

DOI

10.21608/ejhm.2003.18235

Authors

First Name

Esmat A.

Last Name

Shaban

MiddleName

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Affiliation

Assistant Professor, Drug Research Departement, National Center for Radiation Research and Technology, Atomic Energy Authority.

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Volume

13

Article Issue

1

Related Issue

3794

Issue Date

2003-10-01

Receive Date

2018-11-02

Publish Date

2003-10-01

Page Start

99

Page End

111

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 13_Issue 1_Pages 99-111.pdf

PDF . 625.8kB

Link

https://ejhm.journals.ekb.eg/article_18235.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18235

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9

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023