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Correlation of Serum Concentrations of Soluble Thrombomodulin, Soluble Vascular Cell Adhesion Molecule-1, Intracellular Adhesion Molecule -1 And E-Selectin In Patients With System

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Last updated: 03 Jan 2025

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Abstract

To date no specific serological parameters are available to assess disease activity in systemic lupus erythematosus (SLE). The objective of this study was to correlate serum levels of thrombomodulin (TM), intracellular adhesion molecule-1 sICAM-1, vascular cell adhesion molecule-1 sVCAM-1, and E-selectin with standard laboratory tests and clinical indices of disease activity in 40 patients with SLE and 20 apparently healthy persons as controls. According to British Isles Lupus Assessment Group (BILAG) disease activity index, the 40 patients were divided into two groups, the first consisted of 22 with active disease, and the second consisted of 18 patients with inactive SLE. Serum sTM, sICAM-1, sVCAM-I, and E- selectin were measured in their sera, using enzyme linked immuonosorbent assay (ELISA) technique.C-reactiv protein (CRP), Erythrocyte sedimentation rates (ESR) and serum creatinines were measured by standard laboratory tests. Total leukocytic count and hemoglobin concentration were detected by coulter counter. Levels of sTM and sVCAM were highly elevated in the group of patients with active SLE as compared to the inactive one (P<0.0005) while sICAM-1 levels were moderately elevated (P<0.005). E-selectin was poorly correlated with disease activity in SLE (P>0.05). In SLE, the BILAG disease activity index, ESR and serum creatinine correlated best with sTM, sVCAM-1 and E-selectin levels while there was a weak association between CRP levels and the adhesion molecules, and no correlation between CRP level and disease activity. In conclusion, sTM and sVCAM were the most important serological indices of disease activity in SLE and might be valuable serological parameters for monitoring therapy.

DOI

10.21608/ejhm.2003.18227

Authors

First Name

Malak., A.

Last Name

Mohsen

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Affiliation

Clinical Biochemistry Faculty of Medicine for Girls Al- Azhar University, Cairo, Egypt.

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First Name

Magda.A.

Last Name

Gamil

MiddleName

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Affiliation

Clinical Biochemistry Faculty of Medicine for Girls Al- Azhar University, Cairo, Egypt.

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First Name

Maha. I.

Last Name

Shehata

MiddleName

-

Affiliation

Clinical Biochemistry Faculty of Medicine for Girls Al- Azhar University, Cairo, Egypt.

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First Name

Boshra.H,

Last Name

El Zawahry

MiddleName

-

Affiliation

Physiology Departments. Faculty of Medicine for Girls Al- Azhar University, Cairo, Egypt.

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Orcid

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First Name

Salwa.S.I.

Last Name

Afifi

MiddleName

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Affiliation

Microbiology Department Faculty of Pharmacy, Al- Azhar University, Cairo, Egypt.

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Volume

13

Article Issue

1

Related Issue

3794

Issue Date

2003-10-01

Receive Date

2018-11-02

Publish Date

2003-10-01

Page Start

1

Page End

12

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 13_Issue 1_Pages 1-12.pdf

PDF . 347.7kB

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https://ejhm.journals.ekb.eg/article_18227.html

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https://ejhm.journals.ekb.eg/service?article_code=18227

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Correlation of Serum Concentrations of Soluble Thrombomodulin, Soluble Vascular Cell Adhesion Molecule-1, Intracellular Adhesion Molecule -1 And E-Selectin In Patients With Systemic Lupus Erythematosus

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Article

Created At

22 Jan 2023