Beta
ManageSearchChatDiscover
18225

Prophylactic effect of tamoxifen against induction of mammary carcinoma

Article

Last updated: 30 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Tamoxifen (TAM) is a potent anticancer agent known to interrupt the enhanced estrogen activity of malignant mammary gland cells, The mechanism of tamoxifen's anti-tumor activity is primarily due to its anti estrogen action. Female Swiss albino mice were used in the present study and divided into:- normal control group, two Ehrlich ascites carcinoma (EAC) control groups [treated interaperitonealy(IP) and subcutaneously (Sc)], tamoxifen treated only group, tamoxifen pre treated then EAC (S.C) injected group and tamoxifen pre treated then EAC (I.P) injected group. The present results showed a significant decrease in tumor volume and a significant increase in the survival time in the pre-treated group compared to untreated group. There was a pathological change in the uterine tissues of the tamoxifen treated mice in the form of squamous metaplasia and dysplasia of glandular epithelial . The kidney tissues showed a minimal pathological change in the form of a focal renal lesion in the renal tubular epithelium. in conclusion the present study showed that tamoxifen has a prophylactic effect against experimental mammary carcinoma. And exerts some side effects on the histopathological structure of the uterine and kidney tissues. Key words: Tamoxifen, Mammary carcinoma, experimental, prophylactic, side effect.

DOI

10.21608/ejhm.2004.18225

Authors

First Name

Gabri

Last Name

MS

MiddleName

-

Affiliation

Department of Zoology, faculty of science, Helwan University

Email

-

City

-

Orcid

-

First Name

Osman

Last Name

AM

MiddleName

-

Affiliation

Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University

Email

-

City

-

Orcid

-

First Name

El-Sayed

Last Name

MM

MiddleName

-

Affiliation

Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University

Email

-

City

-

Orcid

-

First Name

Negm

Last Name

Somaia.A

MiddleName

-

Affiliation

Pharmacology and Experimental therapeutic Unit, Cancer biology Dep., National Cancer Institute, Cairo University

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

3783

Issue Date

2004-01-01

Receive Date

2018-11-02

Publish Date

2004-01-01

Page Start

104

Page End

114

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 14_Issue 1_Pages 104-114.pdf

PDF . 860.5kB

Link

https://ejhm.journals.ekb.eg/article_18225.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=18225

Order

10

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023