The present work was carried on forty patients with type II diabetes of variable durations of the disease . They were selected from Internal Medicine Department, Sayed, Galal Al-Azhar University Hospital. They were 18 males and 22 females and their age ranged from 41 to 65 years. Twenty normal volunteer subjects were selected as a control group ( 9 males and 11 females and their age ranged from 45 to 65 years).
A full clinical evaluation was done. Labaratory investigations were also performed that included measurement of plasma fasting and postprandial glucose, urea, creatinine, alanine amino transferase (ALT), aspartate aminotransferase (AST) , bilirubin (total and direct), ANA, iron, ferritin, insulin ( fasting and postgrandial as well as hepatitis markers (HbsAg and HCVAb). Liver biopsy was taken for assessment of hepatic tissue iron concentration and histologic assessment. The results revealed that there is a significant difference between cases with type II diabetes and normal control as regarding insulin level (P<0.05). Also a significant relation was noted between high fasting insulin level and increased body mass index (BMI) especially above 30 . Also cases with type II diabetes with steatosis or steatohepatitis had significantly higher fasting insulin level than cases without ( P<0.05). Our results showed that there is a significant high hepatic iron concentration, serum ferritin and serum fasting insulin in patients compared with control group (P<0.05). Also there is a significant increase in HIC and serum ferritin among cases with longer duration of diabetes, together with significant increase in steatosis and steatohepatitis among those cases. In addition, elevated serum ferritin in female cases were of high significance (P<0.01) in comparison to significant elevation in male cases [P<0.05], this may be explained by the fact that females have higher BMI than males.