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18222

The effects of folic acid on carbon black toxicity in mouse embryo in vivo

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Last updated: 30 Jan 2023

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Abstract

The wide commercial use of carbon black oil (CBO) to produce asphalt and other commercial product has resulted in numerous environmental problems and harmful effects on human health especially during the pregnancy. This study, examining the effect of maternal low and high dietary folate intake and to protect the pregnant women from the developmental toxicity of CBO. Virgin females CD1 mice were assigned to diets containing either low 500 or 1300 high (control) nmol folic acid/kg for 6 weeks prior to mating and thought out breeding and gestation. From gestation day (GD 6 to 18) females were given by gavage corn oil or CBO at 500 mg/kg body weight, once daily. On CD 18, mice were weight and killed and the liver removed and weighed. Implantation sites, live and dead fetuses, and resorptions were counted, fetuses were weighed individually and examined for external malformations. The low dietary FA treatment alone and with CBO treatment resulted in low maternal liver as well as low fetal liver folate concentrations relative to the high FA dietary groups. Low FA treatment alone resulted in malformed embryos; there were no embryos affected with malformed in the adequate FA-control group. Low folic acid-CBO treatment resulted in a further increase in the malformed embryos. The percent of malformed embryos in high folic acid-CBO treatment was very low compared to the low folic acid-CBO group. The frequency of chromosomal aberrations in maternal and their fetuses was increased significantly in the low folic-CBO group than high folic acid-CBO group. These results show that the low folate dietary diet with the exposure to  the high levels of CBO toxic material in pregnant women significantly increases the developmental and mutagenic toxicity in the  small fetuses.  

DOI

10.21608/ejhm.2004.18222

Authors

First Name

Roshdy,

Last Name

H.M

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Affiliation

Cell Biology Department, National Research Center Dokki, Cairo, Egypt

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Orcid

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First Name

Bibars,

Last Name

M.H

MiddleName

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Affiliation

Cell Biology Department, National Research Center Dokki, Cairo, Egypt

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Orcid

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Volume

14

Article Issue

1

Related Issue

3783

Issue Date

2004-01-01

Receive Date

2018-11-02

Publish Date

2004-01-01

Page Start

68

Page End

78

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_18222.html

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https://ejhm.journals.ekb.eg/service?article_code=18222

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023