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18191

Evaluation of the hepatoprotective activity of an aqueous extract of olive leaves in male albino rats

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Last updated: 03 Jan 2025

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Abstract

Olive leaf extract is used for centuries in treatment of various medical purposes. This investigation aims to evaluate the hepatoprotective activity of an aqueous extract of olive leaves against overdose paracetamol . 18 rats were divided into three groups, control , 0.5 gm/kg B.W. intrapereitoneally (i. p.) paracetamol treated group and rats were given 2.5 gm /kg BW i. p. of olive leaf aqueous extract for three consecutive days prior to the administration of paracetamol. The results indicated that treatment with paracetamol caused a marked significant increase in serum aspartate aminotransferase (AST),serum alanine aminotransferase (ALT)and alkaline phosphatase (ALP) accompanied by severe congestion of central and hepatic portal veins, vacuolization and ballooning also, a lot of pyknotic nuclei were detected with many small necrotic areas of hepatocytes. Meanwhile group treated by olive leaf extract followed by paracetamol displayed significant reduction in serum (AST),(ALT)and (ALP)associated with nearly normal hepatocyte architecture. In conclusion, an aqueous extract of olive leaves has antioxidant property could protect against liver damage occurred by overdose paracetamol in male albino rats.

DOI

10.21608/ejhm.2004.18191

Authors

First Name

Enas A. M.

Last Name

Khalil

MiddleName

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Affiliation

National Organization For Drug Control And Research

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Volume

15

Article Issue

1

Related Issue

3782

Issue Date

2004-04-01

Receive Date

2018-11-01

Publish Date

2004-04-01

Page Start

118

Page End

123

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 15_Issue 1_Pages 118-123.pdf

PDF . 564.3kB

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https://ejhm.journals.ekb.eg/article_18191.html

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https://ejhm.journals.ekb.eg/service?article_code=18191

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of the hepatoprotective activity of an aqueous extract of olive leaves in male albino rats

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Article

Created At

22 Jan 2023