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18185

Chemoprevention of Barley and Sage against acrylamide-Induced genotoxic, biochemical and histopathological alterations in rats

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Last updated: 30 Jan 2023

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Abstract

Acrylamide (ACR) has recently been found in fried and backed foods, suggesting widespread public exposure. ACR is an industrial chemical material that causes neurotoxicity in humans and was designated as a probable human carcinogen by IARC and USEPA. The aim of the present study was to evaluate the protective effects of barley and sage against ACR mutagenicity and biochemical and histopathological changes in rats. Forty mature male rats were divided into eight groups and were fed barley and/or sage-supplemented diet (5%) with or without ACR (50 mg/kg b.w). The biochemical results revealed that ACR increased Alanine amino transferase (ALT), Aspartate amino transferase (AST), triglycerides (TG), cholesterol and uric acid. Micronucleated polychromatic erythrocytes and chromosomal aberrations in somatic and germ cells were significantly increased in ACR-treated animals. Severe pathological lesions included testicular degeneration, oedema, spermatid giant cells formation and necrosis of spermatid cells were found in the testis of ACR-treated group. The kidney of this group showed degenerative changes. Cotreatment with barley and/or Sage and ACR resulted in a significant improvement in all the parameters tested. It could be concluded that these plants contain antioxidant compounds and may be useful when add as food additive to the food cooked on a higher temperature.  

DOI

10.21608/ejhm.2004.18185

Keywords

acrylamide, Barley, Sage, chromosomal aberrations, kidney, testis

Authors

First Name

Sekena, H.

Last Name

Abd El-Aziem

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Affiliation

Department of Cell Biololgy Faculty of Medicine for girls, Al Azhar University, Cairo, Egypt.

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First Name

Karima, F.

Last Name

Mahrous

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Affiliation

Department of Cell Biololgy Faculty of Medicine for girls, Al Azhar University, Cairo, Egypt.

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First Name

Mosaad A.

Last Name

Abdel-Wahab

MiddleName

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Affiliation

Department of Food Toxicology & Contaminants National Research Centre, Dokki, Cairo, Egypt.

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First Name

Mahmoud A.

Last Name

M

MiddleName

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Affiliation

Department of Pathology. Faculty of Vet. Med. Cairo Univ. Egypt

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Orcid

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First Name

Azza M.

Last Name

Hassan

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Affiliation

Forensic Medicine & Toxicology Department, Faculty of Medicine for girls, Al Azhar University, Cairo, Egypt.

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Volume

15

Article Issue

1

Related Issue

3782

Issue Date

2004-04-01

Receive Date

2018-11-01

Publish Date

2004-04-01

Page Start

40

Page End

56

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 15_Issue 1_Pages 40-56.pdf

PDF . 530.9kB

Link

https://ejhm.journals.ekb.eg/article_18185.html

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https://ejhm.journals.ekb.eg/service?article_code=18185

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023