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18184

Toxic and Teratogenic Effects of Azadirachtin of Neemix-4.5 on Fetuses and Pups of SWR/J Mice

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Last updated: 30 Jan 2023

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Abstract

Inbred normal adult SWR/J mice were used to evaluate the toxic and teratogenic short- and long term effects of various dose levels (0.9, 1.8, 3.0, 9.0, 45.0, which represent 1/100, 1/50, 1/30, 1/10, 1/2 LD50, respectively) of azadirachtin of neemix-4.5 ( insecticide product )on fetuses and pups of pregnant females. The oral administration of the different dose levels of azadirachtin on days 7-12 of gestation or on a 80-day period has not produced any morphological or skeletal changes in fetuses and pups of SWR/J mice. As the pharmacokinetics of azadirachtin and its bioavailability to the fetus are unknown, the essentially negative results obtained in the present study may be due either to the lack of toxic potential or to lack of fetal exposure.  

DOI

10.21608/ejhm.2004.18184

Keywords

Neemix-4.5, Azadirachtin, teratogenicity, Fetotoxicity SWR/J mice

Authors

First Name

F. M.

Last Name

Abou-Tarboush

MiddleName

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Affiliation

King Saud University, College of Science, Department of Zoology

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Orcid

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First Name

H. M.

Last Name

El-Ashmaoui

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Affiliation

National Research Center, Cell Biology Dept., Giza, Egypt.

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Volume

15

Article Issue

1

Related Issue

3782

Issue Date

2004-04-01

Receive Date

2018-11-01

Publish Date

2004-04-01

Page Start

30

Page End

39

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 15_Issue 1_Pages 30-39.pdf

PDF . 326.4kB

Link

https://ejhm.journals.ekb.eg/article_18184.html

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https://ejhm.journals.ekb.eg/service?article_code=18184

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023